Formulation: A solid
Formal Name: 1-O-(4-O-β-D-galactopyranosyl-β-D-glucopyranosyl)-ceramide
Purity: ≥98%
Formula Markup: C53H101NO13 (for tricosanoyl)
Formula Weight: 960,4
Shelf life (days): 1460
CAS Number: 4682-48-8
Notes: Lactosylceramide (LacCer) is an endogenous bioactive sphingolipid. It is expressed on the plasma membrane of human phagocytes and mediates phagocytosis, chemotaxis, and superoxide generation.{41044} LacCer forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors, suggesting a role in cell signaling. Elevated LacCer levels in kidney cortex homogenates and urine are directly correlated with hyperglycemia, insulin resistance, and obesity in db/db transgenic diabetic mice.{41045} It promotes recruitment of CNS-infiltrating monocytes and microglia and enhances neurodegeneration in mice with chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS).{27728} Increased levels of LacCer in atherosclerotic plaques are correlated with increased levels of the pro-inflammatory cytokines IL-6, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein 1β (MIP-1β), as well as lipids and macrophages.{41046} LacCer is also upregulated during the secretory phase of the menstrual cycle.{41047} Lactosylceramide (bovine buttermilk) contains lactosylceramide molecular species with primarily C22:0, C23:0, and C24:0 fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1507]
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