Formulation: A solution in hexane containing 1% triethylamine
Formal Name: 5S-trans-5,6-oxido-7E,9E,11Z,14Z-eicosatetraenoic acid, methyl ester
Purity: ≥97%
Formula Markup: C21H32O3
Formula Weight: 332,5
Shelf life (days): 365
CAS Number: 73466-12-3
Notes: Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities.{595,482} LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively.{482} LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells.{781} Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis.{482} LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.
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