Formulation: A solution in ethanol
Formal Name: 5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid
Purity: ≥97%
Formula Markup: C25H40N2O6S
Formula Weight: 496,7
Shelf life (days): 365
CAS Number: 73836-78-9
Notes: Leukotriene D4 (LTD4) is an active metabolite of LTC4 (Item No. 20210) and a constituent of slow-reacting substance of anaphylaxis (SRS-A).{541,589} It is formed via metabolism of LTC4 by γ-glutamyl transpeptidase. Like LTC4, LTD4 (0.01-0.1 pM) induces contractions in isolated guinea pig parenchymal strips and tracheal spirals.{396} In vivo, LTD4 increases insufflation pressure, a marker of bronchoconstriction, in anesthetized guinea pigs by 100% when administered at a dose of 89 pmol per animal.{4157} It also increases vascular permeability in guinea pig skin when administered intradermally at a dose of 0.1 pmol per animal.
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