Formulation: A solid
Formal Name: (E)-7-((1R,2R,3R)-3-hydroxy-2-((3S,5S,E)-3-hydroxy-5-(methyl-d3)non-1-en-1-yl)-5-oxocyclopentyl)hept-2-enoic acid
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C22H33D3O5
Formula Weight: 383,5
Shelf life (days): 1460
CAS Number: 1263190-37-9
Notes: Limaprost-d3 is intended for use as an internal standard for the quantification of limaprost (Item No. 13810) by GC- or LC-MS. Limaprost is an analog of prostaglandin E1 (PGE1; Item No. 13010) with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is orally active in both rats and guinea pigs at doses of 100 µg/kg as an inhibitor of ADP and collagen-induced platelet aggregation. Limaprost is 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in vitro. Intra-coronary injection (100 ng/kg) or intravenous injection (3 µg/kg) in anesthetized dogs causes vasodilation and increased coronary blood flow by 60-80%. Significant hypotensive effects were seen at 100 and 300 µg/kg orally in rats.{6808}
English
Deutsch
