Formulation: A solid
Formal Name: 1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)-1-propanone
Purity: ≥98%
Formula Markup: C18H20O5
Formula Weight: 316,4
Shelf life (days): 1460
CAS Number: 119425-90-0
Notes: Loureirin B is a flavonoid originally isolated from D. cochinchinensis, a major component of the traditional herbal medicine dragon's blood, and has diverse biological activities.{48437,48438,48439} It inhibits Kv1.3-mediated currents, induces membrane depolarization, and reduces calcium influx in Jurkat T cells.{48437} It also inhibits phytohemagglutinin-induced IL-2 release from these cells. Loureirin B (25 μg/ml) reduces type I collagen and fibronectin protein levels in TGF-β1-stimulated fibroblasts as well as contraction of TGF-β1-stimulated fibroblasts in a gel contraction assay.{48438} It reduces type I collagen and fibronectin protein levels and inhibits phosphorylation of ERK and JNK in isolated human hypertrophic scar tissue. Loureirin B increases glucose absorption and intracellular ATP levels in Ins-1 cells via inhibition of the KATP current and intracellular influx of calcium.{48439}
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