Formulation: A crystalline solid
Formal Name: (3β,5β,15β)-14,15-epoxy-3,5-dihydroxy-bufa-20,22-dienolide
Purity: ≥98%
Formula Markup: C24H32O5
Formula Weight: 400,5
Shelf life (days): 1460
CAS Number: 470-42-8
Notes: Marinobufagenin (MBG) is a bufadienolide steroid first isolated from toads of genus Bufo. It can also be excreted by mammalian cells, particularly kidney cells from hypertensive animals.{32977} MBG inhibits the ouabain-resistant α1 Na+/K+ ATPase subunit (IC50 = 78 nM), impairing a major sodium pump of the kidneys, resulting in natriuresis and arterial hypertension.{32977,32979} Serum and urine levels of MBG are also elevated after cardiac infarction, and a reduced form of MBG, marinobufotoxin, occurs in the plasma of patients with terminal renal failure.{32978,32979} Through its effects on the α1 Na+/K+ ATPase subunit, MBG has profound immediate and prolonged effects on kidney, heart, and vascular functions.{32979}
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