Formulation: A solution in ethanol
Formal Name: L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-12-carboxy-1-[(1S,3Z,6Z)-1-hydroxy-3,6-nonadien-1-yl]-2,4,6,9-dodecatetraen-1-yl]-L-cysteinyl-glycine
Purity: ≥95%
Formula Markup: C32H47N3O9S
Formula Weight: 649,8
Shelf life (days): 365
CAS Number: 1784701-61-6
Notes: Maresin conjugates in tissue regeneration 1 (MCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; Item No. 90310) in macrophages at the site of inflammation.{29715,33727} DHA is oxidized to maresin 1 (MaR1; Item No. 10878), which is then converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase.{27629,33713,27956} MCTR1 accelerates tissue regeneration in planaria (1 and 100 nM).{33727} Pretreatment with MCTR1 (50 ng/mouse, i.p.) prior to E. coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages.{33727} When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR1 reduces the amount of eicosanoids in the exudate.
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