Formulation: A solution in ethanol
Formal Name: N-[2-(3,4-dihydroxyphenyl)ethyl]-5Z,8Z,11Z,14Z-eicosatetraenamide
Purity: ≥98%
Formula Markup: C28H41NO3
Formula Weight: 439,6
Shelf life (days): 365
CAS Number: 199875-69-9
Notes: N-Arachidonoyl dopamine (NADA) is an arachidonoyl amino acid and cannabinoid (CB) receptor 1 agonist (Ki = 250 nM in rat brain membranes, which highly express CB1 receptors).{9213} It is selective for CB1 over CB2 receptors (Ki = 12,000 nM in rat spleen membranes, which highly express CB2 receptors). NADA induces intracellular calcium mobilization in N18TG2 neuroblastoma cells (EC50 = 0.7 µM). It inhibits the proliferation of MCF-7 breast cancer cells (IC50 = 0.25 µM), an effect that can be reversed by the CB1 receptor antagonist SR141716A (rimonabant; Item No. 9000484). NADA (10 mg/kg) induces hypothermia, catalepsy, hypolocomotion, and analgesia in mice.
English
Deutsch
