Formulation: A solution in ethanol
Formal Name: (4Z,7Z,10Z,12E,14E,16R,17S,19Z)-16-(((R)-2-((S)-4-amino-4-carboxybutanamido)-3-((carboxymethyl)amino)-3-oxopropyl)thio)-17-hydroxydocosa-4,7,10,12,14,19-hexaenoic acid
Purity: ≥96%
Formula Markup: C32H47N3O9S
Formula Weight: 649,8
Shelf life (days): 365
CAS Number: 1810710-59-8
Notes: Protectin conjugates in tissue regeneration 1 (PCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; Item No. 90310).{38180} DHA is oxidized to 16S,17S-epoxy-protectin, which is then converted to PCTR1 by glutathione S-transferase.{38180,38178} PCTR1 levels increase during resolution of acute microbial-induced peritonitis in mice.{38179} PCTR1 (30 ng, i.p.) administration 12 hours post-infection increases macrophage numbers and activity and shortens the resolution phase of inflammation by 57%. It also reduces the levels of PGE2 (Item No. 14010), PGD2 (Item No. 12010), and TXB2 (Item No. 19030) in peritoneal exudates.
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