Formulation: A solid
Formal Name: 3β,5β,14-trihydroxy-card-20(22)-enolide
Purity: ≥98%
Formula Markup: C23H34O5
Formula Weight: 390,5
Shelf life (days): 1460
CAS Number: 514-39-6
Notes: Periplogenin is a cardenolide and an active metabolite of periplocin (Item No. 25216) that has been found in P. graeca and has diverse biological activities.{63309,63310,63311} It reduces the activity of porcine Na+/K+ ATPase when used at concentrations of 0.3 or 0.6 µM.{63309} Periplogenin induces apoptosis in U937 and PC3 prostate cancer cells, as well as inhibits the proliferation of these cells (EC50s = 1.41 and 1.2 µM, respectively), when used at concentrations of 0.1 or 0.2 µM. It increases the production of reactive oxygen species (ROS) and induces necroptosis in HaCaT keratinocytes when used at a concentration of 2 µg/ml.{63311} Topical application of periplogenin reduces ear thickness in a mouse model of psoriasis induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014).
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