Formulation: A crystalline solid
Formal Name: 11β,17-dihydroxy-21-(phosphonooxy)-pregna-1,4-diene-3,20-dione, disodium salt
Purity: ≥98%
Formula Markup: C21H27O8P • 2Na
Formula Weight: 484,4
Shelf life (days): 1460
CAS Number: 125-02-0
Notes: Prednisolone phosphate is a prodrug form of the synthetic glucocorticoid prednisolone (Item No. 20866) and a derivative of prednisone (Item No. 20677).{25865} It is hydrolyzed to prednisolone in vivo. Prednisolone phosphate (10 mg/kg), administered in long-circulating liposomes, decreases inflammation and the levels of IL-1β in the synovium, as well as reduces damage to the cartilage matrix in a mouse model of antigen-induced arthritis.{64484} It also reduces tumor growth in B16/F10 melanoma and C26 colon carcinoma mouse models when administered in long-circulating liposomes at a dose of 20 mg/kg.{64485} Formulations containing prednisolone phosphate have been used as anti-inflammatory or immunosuppressive agents.
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