Formulation: A solid
Formal Name: (2R)-3-carboxy-N,N-dimethyl-N-(methyl-d3)-2-(1-oxopropoxy)-1-propanaminium, monochloride
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C10H17D3NO4 • Cl
Formula Weight: 256,7
Shelf life (days): 730
CAS Number: 1334532-19-2
Notes: Propionyl-L-carnitine-d3 is intended for use as an internal standard for the quantification of propionyl-L-carnitine (Item No. 9001873) by GC- or LC-MS. Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids.{24843} Propionyl-L-carnitine increases the basal release of prostaglandin E2 (PGE2; Item No. 14010) and 6-keto Prostaglandin F1α (Item No. 15210) in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B2 (TXB2; Item No. 19030) in non-contaminated cells.{24843} It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal.{47116} Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia.{47117}
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