Formulation: A crystalline solid
Formal Name: 9α,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic acid
Purity: ≥98%
Formula Markup: C20H32O5
Formula Weight: 352,5
Shelf life (days): 730
CAS Number: 41598-07-6
Notes: Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.{416} Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes.{416} PGD2 is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace.{328,1185} In the brain, PGD2 produces normal physiological sleep and lowering of body temperature.{328,1185} Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle.{580} PGD2 inhibits human ovarian tumor cell proliferation with an IC50 of 6.8 µM.{1349}
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