Prostaglandin I2 (sodium salt), CAS 61849-14-7

Formulation: A crystalline solid

Formal Name: 6,9α-epoxy-11α,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid, monosodium salt

Purity: ≥95%

Formula Markup: C20H31O5 • Na

Formula Weight: 374,5

Shelf life (days): 1460

CAS Number: 61849-14-7

Notes: Prostaglandin I2 (PGI2) is an unstable cyclooxygenase metabolite detected first in vascular endothelial cells.{502,443,933} It elevates platelet cAMP and is a potent vasodilator and inhibitor of human platelet aggregation with an IC50 of 5 nM.{4375} PGI2 is stable in basic buffers (pH=8), but it is rapidly hydrolyzed to 6-keto PGF1α in neutral or acidic solutions. The half-life is short both in vivo and in vitro, ranging from 30 seconds to a few minutes. PGI2 is administered by continuous infusion in humans for the treatment of idiopathic pulmonary hypertension.{5466}

• SKU: CAY18220-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 18220-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK