Formulation: A solution in ethanol
Formal Name: 10R,17S-dihydroxydocosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic-21,21,22,22,22-d5 acid
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C22H27D5O4
Formula Weight: 365,5
Shelf life (days): 365
Notes: Protectin D1-d5 is intended for use as an internal standard for the quantification of protectin D1 (Item No. 10010390) by GC- or LC-MS. Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; Item No. 90310).{38180} DHA is oxidized to 16S,17S-epoxy protectin, which is converted to protectin D1 enzymatically. Protectin D1 increases phagocytosis of apoptotic polymorphonuclear leukocytes (PMNs) by macrophages in a non-phlogistic manner and is generated in vitro during macrophage-apoptotic interactions.{14972} It enhances phagocytosis in mice after 24 hours, but not at the initiation or peak of inflammation. It also decreases PMN infiltration in a zymosan-induced mouse model of inflammation when administered at a dose of 300 ng per animal. Protectin D1 (200 µg, i.v.) inhibits increases in neutrophil counts in bronchoalveolar fluid (BALF) and lung myeloperoxidase activity in a mouse model of pulmonary injury and inflammation induced by intratracheal LPS instillation.{48017} It also decreases pulmonary edema and promotes neutrophil apoptosis in BALF.
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