Formulation: A solid
Formal Name: (2S)-7-(β-D-glucopyranosyloxy)-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥98%
Formula Markup: C21H22O10
Formula Weight: 434,4
Shelf life (days): 1460
CAS Number: 529-55-5
Notes: Prunin is a polyketide synthase-derived flavonoid glycoside that has been found in G. glabra and has diverse biological activities.{61558,61559,61560,61561,61562} It inhibits neuraminidase (NA) activity in oseltamivir-sensitive and -resistant H1N1 influenza strains (IC50s = 3 and 4.53 µM, respectively).{61559} Prunin (2 µM) scavenges DPPH radicals in a cell-free assay.{61560} It inhibits the activity of protein tyrosine phosphatase 1B (PTP1B; IC50 = 5.5 µM for the human enzyme) and increases insulin-induced glucose uptake in insulin-resistant HepG2 hepatocellular carcinoma cells in a concentration-dependent manner.{61561} Prunin inhibits the proliferation of, and induces apoptosis in, HL-60 leukemia cells.{61562}
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