PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt), CAS 1628353-02-5

Formulation: A lyophilized powder

Formal Name: D-myo-inositol 1-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl hydrogen phosphate] 3,4,5-tris(dihydrogen phosphate), tetrasodium salt

Purity: ≥98%

Formula Markup: C41H78O22P4 • 4Na

Formula Weight: 1138,9

Shelf life (days): 1825

CAS Number: 1628353-02-5

Notes: The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.{243,8344} PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins.{5241,8674} Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids, see also references {3239} and {8672}.

• SKU: CAY64920-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 64920-500
• Green Labware: No
• Package Unit: 500 µg
• Quantity Unit: STK