Formulation: A solution in ethanol
Formal Name: N-((R)-2-hydroxypropyl)icosa-5Z,8Z,11Z,14Z,17Z-pentaenamide
Purity: ≥98%
Formula Markup: C23H37NO2
Formula Weight: 359,6
Shelf life (days): 365
Notes: N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Eicosapentaenoyl ethanolamide (EPEA) has potential signaling roles in aging, cancer, inflammation, and neurological development.{21496,19917,19740,19623} At least some of EPEA’s effects are mediated through cannabinoid (CB) receptors, while some NAEs also act as vanilloid receptor agonists.{21496,19780} (R)-(−)-Eicosapentaenyl-2’-hydroxy-1’-propylamide is a homolog of EPEA, characterized by the addition of an (R)-β-methyl group at the terminal ethanolamine carbon. A similar modification of arachidonoyl ethanolamide (Item No. 90050) to produce R-2 methanandamide (Item No. 90074) imparts diminished affinity for the CB receptor as well as reduced metabolic stability.{1092} The physiological actions of this compound have not been evaluated.
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