Formulation: A solution in ethanol
Formal Name: 7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-21,21',22,22,22-d5 docosahexaenoic acid
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C22H27D5O5
Formula Weight: 381,5
Shelf life (days): 365
CAS Number: 1881277-32-2
Notes: Resolvin D1-d5 (RvD1-d5) is intended for use as an internal standard for the quantification of RvD1 (Item No. 10012554) by GC- or LC-mass spectrometry. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310).{13989} In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.{14973} RvD1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.{13989} A 17(R)-epimer of RvD1 can also be generated in aspirin-treated samples.{11433} Both RvD1 and its 17(R) configuration reduce human polymorphonuclear leukocyte (PMNL) transendothelial migration, the earliest event in acute inflammation, with EC50 values of ~30 nM.{15718} RvD1 and its aspirin-triggered form also exhibit a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with a maximal inhibition of ~35% at a 10-100 ng dose.{15718}
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