Formulation: A solid
Formal Name: 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol, 1-(hydrogen sulfate), monosodium salt
Purity: ≥95%
Formula Markup: C14H11O6S • Na
Formula Weight: 330,3
Shelf life (days): 1460
CAS Number: 858127-11-4
Notes: Resveratrol-3-O-sulfate is a metabolite of resveratrol (Item Nos. 70675 / 10004235).{37575} In U-937 cells stimulated with LPS, resveratrol-3-O-sulfate (1 µM) decreases the expression of IL-1α, IL-1β, and IL-6 by 61.2, 76.6, and 42.2%, respectively, and decreases the release of TNF-α and IL-6 to similar levels as resveratrol. It has antioxidant activity in a Trolox assay, dose-dependently decreases growth of Caco-2 colorectal adenocarcinoma cells when used at concentrations ranging from 10 to 100 µM, and induces apoptosis at concentrations of 25 and 50 µM.{37576} Resveratrol-3-O-sulfate also displaces rosiglitazone (Item No. 71740) from the outer mitochondrial protein mitoNEET (IC50 = 3.36 µM for the human protein), indicating that it binds to the thiazolidine-2,4-dione (TZD) binding pocket.{37577}
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