Rottlerin, CAS 82-08-6

Formulation: A solid

Formal Name: (2E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one

Purity: ≥90%

Formula Markup: C30H28O8

Formula Weight: 516,5

Shelf life (days): 730

CAS Number: 82-08-6

Notes: Rottlerin was originally identified as an inhibitor of PKCδ (IC50 = 3 μM), but can also inhibit CAM kinase III and a wide range of protein kinases, including PRAK and MAPKAP-K2 (IC50s = 1.9 and 5 μM, respectively).{22472,12847} It can act as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1.{17472} Rottlerin has also been shown to have neuroprotective effects in an MPTP animal model of Parkinson’s disease.{23036}

• SKU: CAY12006-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 12006-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK