(S)-(-)-Linoleyl-1'-Hydroxy-2'-Propylamide

Formulation: A solution in ethanol

Formal Name: N-((S)-1-hydroxypropan-2-yl)octadeca-9Z,12Z-dienamide

Purity: ≥98%

Formula Markup: C21H39NO2

Formula Weight: 337,5

Shelf life (days): 365

Notes: N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Linoleoyl ethanolamide (LOEA) has potential signaling roles in aging and neurological functioning.{19623,11177} LOEA has a weak affinity for cannabinoid (CB) receptors (Ki = 10 and 25 μM for CB1 and CB2, respectively).{7422} It also inhibits fatty acid amide hydrolase (FAAH; Ki = 9 μM) and is hydrolyzed by FAAH, and inhibits voltage-gated K+ channels.{7251,3922,13859} (S)-(−)-Linoleyl-1’-hydroxy-2’-propylamide is a homolog of LOEA, characterized by the addition of an (S)-α-methyl group at the methylene carbon adjacent to the amide nitrogen. A similar modification of arachidonoyl ethanolamide (Item No. 90050) to produce S-1 methanandamide (Item No. 90072) results in a diminished affinity for the CB receptor but greatly improved metabolic stability to aminopeptidase hydrolysis.{1092} The physiological actions of this compound have not been evaluated.

• SKU: CAY9001236-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 9001236-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK