Formulation: A solid
Formal Name: 6-β-D-glucopyranosyl-7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥95%
Formula Markup: C27H30O15
Formula Weight: 594,5
Shelf life (days): 1460
CAS Number: 20310-89-8
Notes: Saponarin is a flavonoid glycoside that has been found in H. vulgare and has diverse biological activities.{66082,66083,66084,66085} It prevents UV- or Fenton’s reagent-induced lipid peroxidation in cell-free assays.{66082} Saponarin (50 and 100 µM) increases intracellular calcium concentrations and induces AMPK phosphorylation in HepG2 and TE 671 cells, as well as increases glucose uptake and reduces glucose production in HepG2 cells.{66083} It inhibits the LPS-induced production of TNF-α and IL-1β in RAW 264.7 cells and induces the expression of skin barrier genes encoding hyaluronan synthase-3, aquaporin-3, and the antimicrobial peptide LL-37 in HaCaT cells.{66084} In vivo, saponarin (80 mg/kg, p.o) reduces cocaine-induced production of thiobarbituric acid reactive substances (TBARS), decreases in hepatic levels of catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPX), and hepatotoxicity in rats.{66085}
English
Deutsch
