Formulation: A solid
Formal Name: (9R,9'S)-5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-[9,9'-bianthracene]-2,2'-dicarboxylic acid
Purity: ≥98%
Formula Markup: C42H38O20
Formula Weight: 862,7
Shelf life (days): 1460
CAS Number: 128-57-4
Notes: Sennoside B is a glycoside that has been found in C. acutifolia and has laxative and gastroprotective activities.{53043,43197} It inhibits H+/K+-ATPase activity in isolated rat stomach mucosa and increases levels of prostaglandin E2 (PGE2; Item No. 14010) in AGS gastric cells when used at a concentration of 100 µM.{43197} Sennoside B (100 mg/kg) increases the intestinal transport rate by 72.2% but has no effect on the gastric emptying rate in mice. It reduces lesion indices by 39.9 and 62.9% in HCl/ethanol-induced gastritis and indomethacin-induced gastric ulcers, respectively, in rats when administered at a dose of 100 mg/kg. Formulations containing sennoside B have been used in the treatment of constipation.
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