Formulation: A solution in chloroform:methanol (2:1)
Shelf life (days): 730
Notes: Galactosylceramides are glycosphingolipids that contain galactose attached to a ceramide containing an N-acyl hydroxy or non-hydroxy fatty acid. They are metabolic precursors to sulfatides, found primarily in nerve tissues, and are the main glycosphingolipids in the central nervous system.{39499,39500} Galactosylceramides are involved in a multitude of cellular processes including cell agglutination, cellular signaling in glycosynapses, cellular development, and activation of T cells.{39499,39500,39501} They accumulate in globoid cells in the brain of patients with Krabbe disease, a disorder characterized by a deficiency in galactosylcerebrosidase activity.{39500} Sulfatides are primarily found in the myelin sheath of oligodendrocytes and Schwann cells, with smaller chain lengths predominant during development and longer chain lengths predominant in mature cells.{40648} They accumulate in the lysosome of patients with metachromatic leukodystrophy, a disorder characterized by arylsulfatase A deficiency.{40650,40646} Sphingomyelins are bioactive sphingolipids found in mammalian cell membranes.{38250} They make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. Sphingolipid Mixture contains bovine hydroxy- and non-hydroxy galactosylcerebrosides, sulfatides, and sphingomyelins. It is intended for use as a reference standard for the identification of these lipids in various sample types by TLC, LC-, or GC-MS. [Matreya, LLC. Catalog No. 1128]
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