Formulation: A solid
Formal Name: (2S,3R,4E)-2-amino-4-octadecene-1,1-d2-1,3-diol-1,2-13C2
Purity: ≥99% deuterated forms (d1-d2)
Formula Markup: C16[13C]2H35D2NO2
Formula Weight: 303,5
Shelf life (days): 1460
CAS Number: 2692623-81-5
Notes: Sphingosine-13C2-d2 (d18:1) is intended for use as an analytical standard for the quantification of sphingosine (d18:1) (Item No. 10007907) by GC- or LC-MS. Sphingosine (d18:1) is formed primarily from the breakdown of ceramide.{13592} Sphingosine (d18:1) inhibits protein kinase C and phosphatidic acid phosphohydrolase, whereas it activates phospholipase D and diacylglycerol (DAG) kinase.{13592} Phosphorylation of sphingosine (d18:1) by sphingosine kinases 1 and 2 (SPHK1, SPHK2) produces sphingosine-1-phosphate, a potent bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.{11895,12477,10628}
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