Formulation: A crystalline solid
Formal Name: (2S,3R,4E)-2-amino-4-octadecene-16,16,17,17,18,18,18-d7-1,3-diol
Purity: ≥99% deuterated forms (d1-d7)
Formula Markup: C18H30D7NO2
Formula Weight: 306,5
Shelf life (days): 730
CAS Number: 1246304-34-6
Notes: Sphingosine-d7 (d18:1) is intended for use as an internal standard for the quantification of sphingosine (d18:1) (Item No. 10007907) by GC- or LC-MS. Sphingosine (d18:1) is formed primarily from the breakdown of ceramide.{13592} Sphingosine (d18:1) inhibits protein kinase C and phosphatidic acid phosphohydrolase, whereas it activates phospholipase D and diacylglycerol (DAG) kinase.{13592} Phosphorylation of sphingosine (d18:1) by sphingosine kinases 1 and 2 (SPHK1, SPHK2) produces sphingosine-1-phosphate, a potent bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.{11895,12477,10628}
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