Formulation: A crystalline solid
Formal Name: 2-((4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-(((2S,3R,4R,5S,6R)-5-(((2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-10-(((2R,5S,6R)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-5-methoxy-9,16-dimethyl-2-oxooxacyclohexadeca-11,13-dien-7-yl)acetaldehyde (Spiramycin I, R = H)
Purity: ≥90%
Formula Markup: C43H74N2O14 (Spiramycin I, R = H)
Formula Weight: 843,1
Shelf life (days): 1460
CAS Number: 8025-81-8
Notes: Spiramycin is a polyketide synthase-derived macrolide antibiotic that has been found in Streptomyces.{22680,46521} It inhibits the binding of tetrahydroleucomycin A3 to E. coli ribosomes (IC50 = 1 µM) and is active against S. aureus, B. subtilis, B. cereus, and M. luteus (MICs = 3.12, 1.56, 3.12, and 0.1 µg/ml, respectively).{62185} Spiramycin protects mice from S. aureus, S. pneumoniae, and P. berghei infections (ED50s = 116.6, 167.9, and 27 mg/kg, respectively).{62186,37704} This product is a mixture of spiramycin I, II, and III, with spiramycin I being the major component.
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