Formulation: A solid
Formal Name: 1-O-(3-O-sulfo-β-D-galactopyranosyl)-ceramide, monosodium salt
Purity: ≥95%
Formula Markup: C42H80NO11S • Na (for stearoyl)
Formula Weight: 830,1
Shelf life (days): 1460
Notes: Sulfatide are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system.{40646} They are produced from the combination of ceramide and UDP-galactose in the endoplasmic reticulum followed by sulfation in the Golgi apparatus. The ceramide portion contains variable fatty acid chain lengths, which are tissue- and pathology-dependent. Sulfatide are primarily found in the myelin sheath of oligodendrocytes and Schwann cells, with smaller chain lengths predominant during development and longer chain lengths predominant in mature cells.{40648} They accumulate in the lysosome of patients with metachromatic leukodystrophy, a disorder characterized by arylsulfatase A deficiency.{40650,40646} Sulfatide are also located in pancreatic β-cells and inhibit insulin release from isolated rat pancreatic islet cells, suggesting a potential role in diabetes.{40644} Sulfatides can induce inflammation in glia in vitro and certain sulfatides, such as C24:1 3’-sulfo-galactosylceramide, can induce an immune response in vitro in mouse splenocytes.{40645,40651} This product contains sulfatide molecular species with primarily C24:1 fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1049]
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