Formulation: A solution in methyl acetate
Formal Name: 9α,11α-dihydroxy-15,15-difluoro-16-phenoxy-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic-3',3',4',4'-d4 acid
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C22H24D4F2O5
Formula Weight: 414,5
Shelf life (days): 730
Notes: Tafluprost (free acid)-d4 is intended for use as an internal standard for the quantification of tafluprost (free acid) (Item No. 10005439) by GC- or LC-MS. Tafluprost (free acid) is an FP receptor agonist (Ki = 4 nM for the human receptor), a derivative of prostaglandin F2α (PGF2α; Item Nos. 16010 / 16020), and an active metabolite of the prodrug tafluprost (Item No. 10005440).{12141} It is formed from tafluprost by hydrolysis and is selective for the FP receptor over the dopamine receptor and PGE2 receptor subtypes EP1 and EP2, as well as a panel of 32 neurological receptors and transporters, at 1 µM. Tafluprost (free acid) induces constriction in isolated cat iris sphincters (EC50 = 0.6 nM).{11598} It also increases the proliferation and migration of, capillary formation by, and COX-2 levels in, human umbilical vein endothelial cells (HUVECs) when used at a concentration of 100 µM.{65907}
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