Formulation: A solution in methanol at 100 µg/ml (nominal); see CofA for verified concentration
Formal Name: 2-[[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid
Purity: ≥95%
Formula Markup: C26H45NO6S
Formula Weight: 499,7
Shelf life (days): 1825
CAS Number: 516-50-7
Notes: Taurodeoxycholic acid is a taurine-conjugated form of the secondary bile acid deoxycholic acid (Item Nos. 20756 / 18231).{33902} Taurodeoxycholic acid stimulates chloride ion secretion through calcium-activated chloride ion channels and cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cell monolayers when applied basolaterally.{29486} Serum levels of taurodeoxycholic acid increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.{33902} Taurodeoxycholic acid MaxSpec® standard is a quantitative grade standard of taurodeoxycholic acid (Item No. 15935) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. The verified concentration is provided on the certificate of analysis. This taurodeoxycholic acid MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
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