Formulation: A crystalline solid
Formal Name: 2-[[(3α,5β)-3-hydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonic acid, monosodium salt
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C26H40D4NO5S • Na
Formula Weight: 509,7
Shelf life (days): 730
CAS Number: 2410279-97-7
Notes: Taurolithocholic acid-d4 (TLCA-d4) is intended for use as an internal standard for the quantification of TLCA (Item No. 17275) by GC- or LC-MS. TLCA is a taurine-conjugated form of the secondary bile acid lithocholic acid (Item No. 20253).{33902} TLCA (75 μM) increases caspase-3 and -7 activity in Hep3B cells transfected with sodium taurocholate cotransporting peptide (NTCP), but not nontransfected Hep3B cells.{28235} It has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis.{28234,43818} Serum levels of TLCA increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.{33902}
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