Telocinobufagin, CAS 472-26-4

Formulation: A crystalline solid

Formal Name: 3β,5β,14-trihydroxy-bufa-20,22-dienolide

Purity: ≥98%

Formula Markup: C24H34O5

Formula Weight: 402,5

Shelf life (days): 1460

CAS Number: 472-26-4

Notes: Telocinobufagin is a cardiotonic steroid that has been found in skin secretions of the toad B. rubescens and has diverse biological activities.{29914,46344,46345,46346} It inhibits human kidney Na+/K+-ATPase with an IC50 value of 44.2 nM.{46345} Telocinobufagin (9.9 μg/ml) increases contraction force in isolated frog ventricle strips by 30.2%.{46344} It is cytotoxic to HL-60, HCT8, SF295, MDA-MB-435 cancer cells and human peripheral blood lymphocytes (IC50s = 0.06, 0.06, 0.03, 0.11, and 0.05 μM, respectively).{46346} Telocinobufagin is also active against E. coli and S. aureus (MICs = 64 and 128 μg/ml, respectively).{46344}

• SKU: CAY27981-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 27981-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK