Formulation: A solid
Formal Name: (3α,5α)-3,21-dihydroxy-pregnan-20-one
Purity: ≥95%
Formula Markup: C21H34O3
Formula Weight: 334,5
Shelf life (days): 1460
CAS Number: 567-02-2
Notes: 3α,5α-THDOC is a neurosteroid and positive allosteric modulator of GABAA receptors.{17635} It inhibits binding of the convulsant t-butylbicyclophosphorothionate (TBPS) and increases binding of the benzodiazepine flunitrazepam to rat synaptosomal membrane preparations in a concentration-dependent manner.{41027} 3α,5α-THDOC potentiates GABA-induced chloride currents in cultured rat hippocampal and spinal cord neurons. It inhibits seizures induced by pilocarpine or pentylenetetrazol (PTZ; Item No. 18682) in mice (ED50s = 7.3 and 15 mg/kg, respectively).{52179} 3α,5α-THDOC (20 mg/kg) increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic activity.{52180}
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