Formulation: A solid
Formal Name: 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[[6-O-[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]-β-D-glucopyranosyl]oxy]-4H-1-benzopyran-4-one
Purity: ≥98%
Formula Markup: C30H26O13
Formula Weight: 594,5
Shelf life (days): 1460
CAS Number: 20316-62-5
Notes: Tiliroside is a polyketide synthase-derived flavonoid glycoside that has been found in Q. ilex and has diverse biological activities.{58639,42158,58640,58641,58642} It inhibits carbonic anhydrase VII (CAVII; Ki = 4.6 nM), but not CAI, CAII, CAIV, or CAXII (Kis = >10, >10, 5.46, and 0.134 µM, respectively), in a cell-free assay.{42158} Tiliroside scavenges DPPH (Item No. 14805) and superoxide radicals (IC50s = 12.8 and 42 µM, respectively) and is cytotoxic to Jurkat, HepG2, and COLO 205 cells (IC50s = 11.6, 14.3, and 55.4 µM, respectively).{58640} It reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) with an ID50 value of 0.357 mg/ear.{58641} Tiliroside (100 mg/kg) decreases triglyceride accumulation in the liver and skeletal muscle in high-fat diet-fed KKAy diabetic mice.{58642}
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