Formulation: A crystalline solid
Formal Name: 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide
Purity: ≥95%
Formula Markup: C17H22N2O3
Formula Weight: 302,4
Shelf life (days): 1460
CAS Number: 58880-19-6
Notes: Trichostatin A is a potent, reversible inhibitor of class I, II, and IV histone deacetylases (HDACs). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of HDAC1 with an IC50 value of 70 nM.{8150} Trichostatin A selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.{4011}