Formulation: A solution in methyl acetate
Formal Name: 9,11-dideoxy-9α,11α-methanoepoxy-prosta-5Z,13E-dien-1-oic acid, methyl ester
Purity: ≥98%
Formula Markup: C24H39NO5
Formula Weight: 421,6
Shelf life (days): 365
Notes: U-46619 is a stable analog of the endoperoxide PGH2, and a TP receptor agonist.{8322} It exhibits properties similar to TXA2, causing platelet shape change, aggregation, and contraction of vascular smooth muscle.{490,714} Mean EC50 values for shape change in human, rat, and rabbit platelets are 4.8, 6.0, and 7.3 nM respectively, and for aggregation, are 82, 145, and 65 nM, respectively.{1168} U-46619 glycine methyl ester contains a modification at the C-1 position of U-46619 that may uniquely alter its binding properties to the TP receptor or any of the PGH2-metabolizing enzymes. As a stable PGH2 analog, it could therefore be a useful tool to explore the inhibition of various enzymes in the arachidonic acid metabolic pathway. U-46619 glycine methyl ester may also serve as a lipophilic prodrug form of U-46619 that will alter its distribution and pharmacokinetic properties. There are no published reports on the biological activity of U-46619 glycine methyl ester.
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