Formulation: A crystalline solid
Formal Name: (3α,5β,7β)-3,7-dihydroxy-cholan-24-oic acid
Purity: ≥95%
Formula Markup: C24H40O4
Formula Weight: 392,6
Shelf life (days): 730
CAS Number: 128-13-2
Notes: Ursodeoxycholic acid (UDCA) is a secondary bile acid formed via epimerization of chenodeoxycholic acid (CDCA; Item Nos. 10011286 / 35346).{48224,48225} UDCA is also a metabolite of lithocholic acid (LCA; Item No. 20253) in human liver microsomes.{48226} It inhibits taurocholic acid (Item No. 16215) uptake in HeLa cells expressing recombinant human sodium/taurocholate cotransporting polypeptide (NTCP) with an IC50 value of 3.6 μM.{24182} UDCA (50 μM) inhibits apoptosis induced by deoxycholic acid (DCA; Item Nos. 20756 / 18231) or ethanol in primary rat hepatocytes.{48227} Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis.
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