Product Description: 4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of CYP1A2-mediated phenacetin O-deethylation with an IC50 value of 1.7μM and a Ki value of 2.6 μM. 4,5-Dimethoxycanthin-6-one, as an alkaloid, is isolated from the wood of Picrasma quassioides BENNET (Simaroubaceae)[1][2].
Applications: Metabolism-sugar/lipid metabolism
Formula: C16H12N2O3
References: [1]Taichi O, et al. Studies on the Constituents of Picrasma quassioides BENNET. III. The Alkaloidal Constituents/[2]Miao X,et al. In vitro metabolism of 4, 5-dimethoxycanthin-6-one by human liver microsomes and its inhibition on human CYP1A2. Life Sci. 2017;190:46-51.
CAS Number: 18110-87-7
Molecular Weight: 280.28
Compound Purity: 98.68
Research Area: Metabolic Disease
Solubility: DMSO : 10 mg/mL (ultrasonic)
Target: Cytochrome P450