Product Description: 4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose), a glucose derivative, is a competitive exofacial binding-site inhibitor on glucose transporter 1 (GLUT1) with a Ki of 12 mM for wild-type 2-deoxy-D-glucose transport[1][2][3].
Applications: Metabolism-sugar/lipid metabolism
Formula: C8H14O6
References: [1]M Hashiramoto, et al. Site-directed Mutagenesis of GLUT1 in Helix 7 Residue 282 Results in Perturbation of Exofacial Ligand Binding. J Biol Chem. 1992 Sep 5;267(25):17502-7./[2]Malay Patra, et al. A Potent Glucose-Platinum Conjugate Exploits Glucose Transporters and Preferentially Accumulates in Cancer Cells. Angew Chem Int Ed Engl. 2016 Feb 12;55(7):2550-4./[3]G F Baker, et al. The Permeation of Human Red Cells by 4,6-O-ethylidene- -D-glucopyranose (Ethylidene Glucose). J Physiol. 1973 May;231(1):129-42.
CAS Number: 13224-99-2
Molecular Weight: 206.19
Compound Purity: 98.0
Research Area: Metabolic Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : 125 mg/mL (ultrasonic)
Target: Endogenous Metabolite;GLUT
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