Product Description: 4′-Hydroxywogonin (8-Methoxyapigenin), a flavonoid, could be isolated from a variety of plants including Scutellaria barbata and Verbena littoralis. 4′-Hydroxywogonin has anti-inflammatory activity via TAK1/IKK/NF-κB, MAPKs and PI3/AKT signaling pathways. 4′-Hydroxywogonin inhibits angiogenesis by disrupting PI3K/AKT signaling. 4′-Hydroxywogonin inhibits cell proliferation and induces apoptosis[1][2][3].
Applications: COVID-19-immunoregulation
Formula: C16H12O6
References: [1]Fan C, et, al. 4'-Hydroxywogonin suppresses lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages and acute lung injury mice. PLoS One. 2017 Aug 8;12(8):e0181191.
CAS Number: 57096-02-3
Molecular Weight: 300.26
Research Area: Cancer; Inflammation/Immunology; Cardiovascular Disease
Solubility: 10 mM in DMSO
Target: Akt;Apoptosis;Bcl-2 Family;Caspase;IKK;Interleukin Related;NF-κB;p38 MAPK;PI3K;Reactive Oxygen Species;TNF Receptor
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