Product Description: 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide), an important steroid from medicinal mushroom, exerts antitumor activity in several tumor types. 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol inhibits HT29 cell growth by inducing CDKN1A expression, thus causing cell cycle arrest and apoptosis[1][2].
Applications: Cancer-programmed cell death
Formula: C28H42O3
References: [1]Kobori M, Yoshida M, Ohnishi-Kameyama M, Takei T, Shinmoto H. 5alpha,8alpha-Epidioxy-22E-ergosta-6,9(11),22-trien-3beta-ol from an edible mushroom suppresses growth of HL60 leukemia and HT29 colon adenocarcinoma cells. Biol Pharm Bull. 2006;29(4):755-759. /[2]Zheng L, et al. Apoptosis induced by 9,11 dehydroergosterol peroxide from Ganoderma Lucidum mycelium in human malignant melanoma cells is Mcl 1 dependent. Mol Med Rep. 2018;18(1):938-944.
CAS Number: 86363-50-0
Molecular Weight: 426.63
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Apoptosis;Endogenous Metabolite
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