Product Description: 5-Methoxysterigmatocystin is a mycotoxin with cytotoxic and genotoxic properties. 5-Methoxysterigmatocystin exhibits cytotoxicity against cancer cells A549 and HepG2 (IC50 of 5.5 and 0.7 μM), and induces DNA damage. 5-Methoxysterigmatocystin is a photosensitizer, which utilizes the visible to generate singlet oxygen (1O2)[1][2].
Applications: Cancer-programmed cell death
Formula: C19H14O7
References: [1]Dabelić S, et al., Sterigmatocystin, 5-Methoxysterigmatocistin, and Their Combinations Are Cytotoxic and Genotoxic to A549 and Hepg2 Cells and Provoke Phosphorylation of Chk2, but Not Fancd2 Checkpoint Proteins. Toxins (Basel). 2021 Jun 30;13(7):464. /[2]Espinoza C, et al., Photosensitizer ability of 5-methoxysterigmatocystin isolated from aquatic fungus Acremonium persicinum[J]. Electronic Journal of Biotechnology, 2023, 62: 21-26.
CAS Number: 22897-08-1
Molecular Weight: 354.31
Research Area: Cancer
Target: Others
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