Product Description: 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2[1].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C18H16O6
References: [1]Sudha, A, et al. Protective effect of 5-hydroxy-3′,4′,7-trimethoxyflavone against inflammation induced by lipopolysaccharide in RAW 264.7 macrophage: in vitro study and in silico validation. Medicinal Chemistry Research, 2016,25(9), 1754–1767.
CAS Number: 29080-58-8
Molecular Weight: 328.32
Compound Purity: 99.28
Research Area: Inflammation/Immunology
Solubility: DMSO : 20 mg/mL (ultrasonic)
Target: COX;Interleukin Related;TNF Receptor
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