Product Description: Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca2+-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46[1][2][3].
Formula: C30H40O6
References: [1]Zhang W, et al. Total synthesis of absinthin. J Am Chem Soc. 2005 Jan 12;127(1):18-9./[2]Lachenmeier DW, et al. Absinthe--a review. Crit Rev Food Sci Nutr. 2006;46(5):365-77./[3]Talmon M, et al. Absinthin, an agonist of the bitter taste receptor hTAS2R46, uncovers an ER-to-mitochondria Ca2+-shuttling event. J Biol Chem. 2019 Aug 16;294(33):12472-12482./[4]Guo N, et al. Absinthin attenuates LPS-induced ALI through MIP-1α-mediated inflammatory cell infiltration. Exp Lung Res. 2015;41(9):514-24. /[5]Talmon M, et al. Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells. J Nat Prod. 2020 Jun 26;83(6):1740-1750.
CAS Number: 1362-42-1
Molecular Weight: 496.64
Research Area: Others
Solubility: 10 mM in DMSO
Target: Others
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