Product Description: Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].
Applications: Cancer-programmed cell death
Formula: C7H16ClNO2
Citations: Biomed Pharmacother. 2024 Jul 12:177:117105./bioRxiv. 2023 Oct 13./BMC Pulm Med. 2021 Jun 5;21(1):189./Front Cardiovasc Med. 2021 Jun 16;8:679240./J Hazard Mater. 2023 Dec 14, 133248./Mol Metab. 2023 Sep 26, 101811./Redox Biol. 2023 Dec 18:69:103004./Int J Mol Sci. 2023 Apr 16, 24(8), 7356./Nat Commun. 2023 Sep 21;14(1):5891.
References: [1]Prashant Tiwari, et al. Basic and modern concepts on cholinergic receptor: A review. Asian Pac J Trop Dis. 2013 Oct;3(5): 413-420./[2]A Young, et al. Diarrhoea of famine and malnutrition--investigations using a rat model. 2--Ileal hypersecretion induced by starvation. Gut. 1990 Feb;31(2):162-9./[3]Xia Lei, et al. Effects of acetylcholine chloride on intracellular calcium concentration of cultured sweat gland epithelial cells. Arch Dermatol Res. 2008 Aug;300(7):335-41./[4]P F Zabrodskii, et al. Effect of acetylcholine on mortality of mice from sepsis and proinflammatory cytokine production. Bull Exp Biol Med. 2011 Jan;150(3):340-2./[5]Zhaolin Chen, et al. Inhibition of p53 Mutant Peptide Aggregation In Vitro by Cationic Osmolyte Acetylcholine Chloride. Protein Pept Lett. 2017;24(4):353-357.
CAS Number: 60-31-1
Molecular Weight: 181.66
Compound Purity: 98.0
Research Area: Neurological Disease; Cancer
Solubility: DMSO : 62.5 mg/mL (ultrasonic)/H2O : 100 mg/mL (ultrasonic)
Target: Calcium Channel;Endogenous Metabolite;nAChR
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