Product Description: Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].
Applications: Cancer-programmed cell death
Formula: C5H7ClN2O3
References: [1]Kreuzer J, et al. Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition. Chem Sci. 2014 Dec 1;6(1):237-245. Epub 2014 Sep 26./[2]Chikhale EG, et al. Carrier-mediated transport of the antitumor agent acivicin across the blood-brain barrier. Biochem Pharmacol. 1995 Mar 30;49(7):941-5./[3]Delphine Waniusiow, et al. Toluene-induced hearing loss in acivicin-treated rats. Neurotoxicol Teratol. May-Jun 2008;30(3):154-60.
CAS Number: 42228-92-2
Molecular Weight: 178.57
Compound Purity: 98.26
Research Area: Cancer; Infection
Solubility: H2O : 6.67 mg/mL (ultrasonic)
Target: Parasite
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