Product Description: Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo[1][2].
Applications: Cancer-Kinase/protease
Formula: C37H56O11
References: [1]Yang ZC, et al. Actein enhances TRAIL effects on suppressing gastric cancer progression by activating p53/Caspase-3 signaling. Biochem Biophys Res Commun. 2018 Mar 18;497(4):1177-1183./[2]Ji L, et al. Actein induces autophagy and apoptosis in human bladder cancer by potentiating ROS/JNK and inhibiting AKT pathways. Oncotarget. 2017 Nov 1;8(68):112498-112515.
CAS Number: 18642-44-9
Molecular Weight: 676.83
Compound Purity: 98.58
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Akt;Apoptosis;Autophagy;JNK
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