Anemarsaponin B, CAS 139051-27-7

Product Description: Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect [1].

Applications: COVID-19-immunoregulation

Formula: C45H74O18

References: [1]Kim JY, et al. Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of <i>Anemarrhena asphodeloides</i> in LPS-induced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-kappaB and p38 pathways. Food Chem Toxicol. 2009 Jul;47(7):1610-7.

CAS Number: 139051-27-7

Molecular Weight: 903.06

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: COX;MEK;NF-κB;NO Synthase

• SKU: MEXHY-N0811-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-N0811-5
• Package Unit: 5 mg
• Quantity Unit: STK