Product Description: Artobiloxanthone (Compound AA3) exhibits antitumor activity, particularly against oral squamous cell carcinoma (OSCC). Artobiloxanthone inhibits Akt/mTOR pathway and STAT3 pathway, inhibits proliferation of SAS and T.Tn (with IC50 of 11 and 22 μM), and inhibits the cancer cell migration. Artobiloxanthone arrests cell cycle at S phase, and induces apoptosis in OSCC cells through activation of caspase 3/9[1].
Applications: Cancer-Kinase/protease
Formula: C25H22O7
References: [1]Aswathy M, et al., Natural Prenylflavones from the Stem Bark of Artocarpus altilis: Promising Anticancer Agents for Oral Squamous Cell Carcinoma Targeting the Akt/mTOR/STAT-3 Signaling Pathway. ACS Omega. 2024 May 24;9(23):24252-24267.
Molecular Weight: 434.44
Research Area: Cancer
Target: Apoptosis;Bcl-2 Family;Caspase;COX;MMP;STAT
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